DIALIGN: finding local similarities by multiple sequence alignment
نویسندگان
چکیده
منابع مشابه
DIALIGN: finding local similarities by multiple sequence alignment
MOTIVATION DIALIGN is a new method for pairwise as well as multiple alignment of nucleic acid and protein sequences. While standard alignment programs rely on comparing single residues and imposing gap penalties, DIALIGN constructs alignments by comparing whole segments of the sequences. No gap penalty is employed. This point of view is especially adequate if sequences are not globally related,...
متن کاملFinding functional sequence elements by multiple local alignment.
Algorithms that detect and align locally similar regions of biological sequences have the potential to discover a wide variety of functional motifs. Two theoretical contributions to this classic but unsolved problem are presented here: a method to determine the width of the aligned motif automatically; and a technique for calculating the statistical significance of alignments, i.e. an assessmen...
متن کاملDIALIGN: multiple DNA and protein sequence alignment at BiBiServ
DIALIGN is a widely used software tool for multiple DNA and protein sequence alignment. The program combines local and global alignment features and can therefore be applied to sequence data that cannot be correctly aligned by more traditional approaches. DIALIGN is available online through Bielefeld Bioinformatics Server (BiBiServ). The downloadable version of the program offers several new pr...
متن کاملMultiple Sequence Alignment Using the Quasi-concave Function Optimization Based on the DIALIGN Combinatorial Structures
Multiple sequence alignment is usually considered as an optimization problem, which has a statistical and a structural component. It is known that in the problem of protein sequence alignment a processed sample is too small and not representative in the statistical sense though this information can be sufficient if an appropriate structural model is used. In order to utilize this information a ...
متن کاملDIALIGN at GOBICS—multiple sequence alignment using various sources of external information
DIALIGN is an established tool for multiple sequence alignment that is particularly useful to detect local homologies in sequences with low overall similarity. In recent years, various versions of the program have been developed, some of which are fully automated, whereas others are able to accept user-specified external information. In this article, we review some versions of the program that ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 1998
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/14.3.290